Optimizing Coordination in the Metformin Supply Chain Using Quantity Discounts and Government Subsidies: A Case Study of Iran's Healthcare System

Authors

https://doi.org/10.22105/ahse.v3i2.59

Abstract

Access to essential medications like metformin in Iran's healthcare system is significantly enhanced by preventing financial distress and ensuring robust cash flow through integrating quantity discounts and government subsidies. This study investigates their role in optimizing supply chain coordination, enhancing profitability, and reducing costs. By examining a two-tier pharmaceutical supply chain involving collaboration among government entities, pharmaceutical companies, and insurers under price controls, the research employs analytical models to assess their impact on stakeholder coordination and overall efficiency. The findings demonstrate that these strategies improve collaboration and optimize total supply chain profits. This study provides actionable insights into leveraging quantity discounts and government subsidies to strengthen coordination in Iran's pharmaceutical supply chain, ultimately ensuring equitable access to high-quality medications. 

Keywords:

Coordination, Pharmaceutical supply chain, Discount, Insurance policies, Government subsidies, Logistics

References

  1. [1] Alkhouri, M. (2024). Pharmaceutical supply chain-new obstacles and challenges [Thesis]. https://dspace.lib.uom.gr/handle/2159/30186

  2. [2] Zhou, N., Li, S., Zhao, G., Li, C., & Yu, N. (2023). Medical service pricing and pharmaceutical supply chain coordination contracts under the zero-markup drug policy. Frontiers in Public Health, 11. https://doi.org/10.3389/fpubh.2023.1208994

  3. [3] Tian, B., Yu, L., & Chang, X. (2024). Examining supply chain financing: A comparative and coordination analysis under a buyback contract. RAIRO-Operations Research, 58(2), 1899–1925. https://doi.org/10.1051/ro/2024062

  4. [4] Peng, Y., Lu, J., Cheng, T. C. E., & Ji, M. (2024). Revenue sharing or not? Coordination of the buy-online-and-pickup-in-store supply chain. International Transactions in Operational Research, 31(3), 1917–1948. https://doi.org/10.1111/itor.13218

  5. [5] Heydari, J., & Asl-Najafi, J. (2021). A revised sales rebate contract with effort-dependent demand: a channel coordination approach. International Transactions in Operational Research, 28(1), 438–469. https://doi.org/10.1111/itor.12556

  6. [6] Kord, H., & Samouei, P. (2023). Coordination of humanitarian logistic based on the quantity flexibility contract and buying in the spot market under demand uncertainty using NSGA-II and NRGA algorithms. Expert Systems with Applications, 214, 119187. https://doi.org/10.1016/j.eswa.2022.119187

  7. [7] Li, Y., Wu, D., & Dolgui, A. (2022). Optimal trade credit coordination policy in dual-channel supply chain with consumer transfer. International Journal of Production Research, 60(15), 4641–4653. https://doi.org/10.1080/00207543.2021.1912427

  8. [8] Huang, Y. S., Ho, J. W., Jian, H. J., & (Bill) Tseng, T. L. (2021). Quantity discount coordination for supply chains with deteriorating inventory. Computers & Industrial Engineering, 152, 106987. https://doi.org/10.1016/j.cie.2020.106987

  9. [9] Arshinder, K., Kanda, A., & Deshmukh, S. G. (2011). A review on supply chain coordination: Coordination mechanisms, managing uncertainty and research directions. In Supply chain coordination under uncertainty (pp. 39–82). Berlin, Heidelberg: Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-19257-9_3

  10. [10] Ji, J., & Yi, Y. (2022). Value variations of political ties in the acquisition of R&D capabilities: The roles of non-SOEs and dysfunctional competition. Industrial Marketing Management, 101, 1–11. https://doi.org/10.1016/j.indmarman.2021.11.012

  11. [11] Yu, X., Li, C., Shi, Y., & Yu, M. (2010). Pharmaceutical supply chain in China: Current issues and implications for health system reform. Health Policy, 97(1), 8–15. https://doi.org/10.1016/j.healthpol.2010.02.010

  12. [12] Ma, J., Hou, Y., Wang, Z., & Yang, W. (2021). Pricing strategy and coordination of automobile manufacturers based on government intervention and carbon emission reduction. Energy Policy, 148, 111919. https://doi.org/10.1016/j.enpol.2020.111919

  13. [13] Maleki, F., Yaghoubi, S., & Fander, A. (2023). Organic level vs. sales effort in coordination of green food supply chain for deteriorating items. Environment, Development and Sustainability, 25(11), 13065–13097. https://doi.org/10.1007/s10668-022-02603-0

  14. [14] Yousefi, N., Moradi, N., Dinarvand, R., Ghiasi, G., Inanloo, H., & Peiravian, F. (2019). Policies to improve access to pharmaceutical products in shortage: The experience of Iran food and drug administration. DARU Journal of Pharmaceutical Sciences, 27(1), 169–177. https://doi.org/10.1007/s40199-019-00259-2

  15. [15] Bashaar, M., Hassali, M. A., & Saleem, F. (2015). Community pharmacists’ attitudes toward the quality and price of locally manufactured generic medicines in Kabul, Afghanistan. Journal of Pharmaceutical Policy and Practice, 8(1), 16. https://doi.org/10.1186/s40545-015-0037-3

  16. [16] Matinfard, S., Yaghoubi, S., & Kharaji Manouchehrabadi, M. (2022). Impact of government policies on photovoltaic supply chain considering quality in the power distribution system: A case study. Environmental Science and Pollution Research, 29(39), 58810–58827. https://doi.org/10.1007/s11356-022-19884-7

Published

2026-06-04

How to Cite

Otrodi, F., Khademi Zare, H., Fakhrzad, M. B., & Zare Mehrjerdi, Y. (2026). Optimizing Coordination in the Metformin Supply Chain Using Quantity Discounts and Government Subsidies: A Case Study of Iran’s Healthcare System. Annals of Healthcare Systems Engineering, 3(2), 84-92. https://doi.org/10.22105/ahse.v3i2.59